2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-105196
    DAT-582 141034-42-6 98%
    DAT-582 is a serotonin 3 (5-HT3) receptor antagonist that has an antiemetic effect.
    DAT-582
  • HY-105332
    CRA1000 226948-11-4 98%
    CRA1000 is an orally active, selective and competitive CRF1 receptor antagonist with anxiolytic- and antidepressant-like properties.
    CRA1000
  • HY-105389
    Tramadol N-oxide 147441-56-3 98%
    Tramadol N-oxide (RWJ 38705) is an analgesic. Tramadol N-oxide sproduces dose-related, long-lasting antinociception. Tramadol N-oxide has affinity for μ opioid receptor (Ki = 38.5 μM) and δ, κ receptors (Ki > 100 μM). Tramadol N-oxide can be used for the study of analgesic effect.
    Tramadol N-oxide
  • HY-105567
    Carbiphene 15687-16-8 98%
    Carbiphene is a GABAA receptor allosteric modulator. Carbiphene inhibits [35S] TBPS binding and enhances [3H] muscimol binding on rat forebrain membranes, acting on specific GABAA receptor subsets. Carbiphene can be used in research related to schizophrenia.
    Carbiphene
  • HY-10559R
    Nelotanserin (Standard) 839713-36-9 98%
    Nelotanserin (Standard) is the analytical standard of Nelotanserin (HY-10559). This product is intended for research and analytical applications. Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively.
    Nelotanserin (Standard)
  • HY-10560R
    Temanogrel (Standard) 887936-68-7 98%
    Temanogrel (Standard) is the analytical standard of Temanogrel. This product is intended for research and analytical applications. Temanogrel is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM.
    Temanogrel (Standard)
  • HY-10562R
    Ketanserin (Standard) 74050-98-9 98%
    Ketanserin (Standard) is the analytical standard of Ketanserin. This product is intended for research and analytical applications. Ketanserin is a selective 5-HT2 receptor antagonist. Ketanserin also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).
    Ketanserin (Standard)
  • HY-105637
    Cropropamide 633-47-6 98%
    Cropropamide is a component of the respiratory stimulant Prethamide. Cropropamide increases locomotor activity in rats.
    Cropropamide
  • HY-10588R
    Bay K 8644 (Standard) 71145-03-4 98%
    Bay K 8644 (Standard) is the analytical standard of Bay K 8644. This product is intended for research and analytical applications. Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644. Bay K 8644 is a L-type Ca2+ channel agonist with an EC50 of 17.3 nM. Bay K 8644 increases Ca2+ influx through sarcolemmal Ca2+ channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects.
    Bay K 8644 (Standard)
  • HY-10590R
    TWS119 (Standard) 601514-19-6 98%
    TWS119 (Standard) is the analytical standard of TWS119. This product is intended for research and analytical applications. TWS119 is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.
    TWS119 (Standard)
  • HY-10591R
    Neuropathiazol (Standard) 880090-88-0
    Neuropathiazol (Standard) is the analytical standard of Neuropathiazol (HY-10591). This product is intended for research and analytical applications. Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells.
    Neuropathiazol (Standard)
  • HY-106017
    Nerispirdine 119229-65-1 98%
    Nerispirdine is an ion channel inhibitor with IC50s of 3.6, 3.7 and 11.9 μM against K(v)1.1, K(v)1.2 and voltage-dependent Na(+) channel, respectively. Nerispirdine is a 4-aminopyridine (4-AP, HY-B0604) derivative and can be utilized in research on neurological disorders.
    Nerispirdine
  • HY-10633R
    SB-705498 (Standard) 501951-42-4 98%
    SB-705498 (Standard) is the analytical standard of SB-705498 (HY-10633). This product is intended for research and analytical applications. SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1.
    SB-705498 (Standard)
  • HY-10634R
    AMG 517 (Standard) 659730-32-2 98%
    AMG 517 (Standard) is the analytical standard of AMG 517. This product is intended for research and analytical applications. AMG 517 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with an IC50 of 0.5 nM.
    AMG 517 (Standard)
  • HY-106415
    Terflavoxate 86433-40-1 98%
    Terflavoxate is a flavone derivative with spasmolytic properties. Terflavoxate has Ca2+-antagonistic effect is mainly responsible for Terflavoxate smooth muscle relaxant properties. Terflavoxate has the potential for overactive detrusor research.
    Terflavoxate
  • HY-106424
    Soretolide 130403-08-6 98%
    Soretolide is an antiepileptic agent. Soretolide is effective in maximal electroshock-induced seizure (MES) test in rodents. Soretolide inhibits metabolism of Phenytoin (HY-B0448). Soretolide exhibits a good pharmacokinetic character in rats model.
    Soretolide
  • HY-106437
    ELB-139 188116-08-7 98%
    ELB-139 is a progesterone analogue. ELB-139 is a GABAA receptor partial agonist. ELB-139 has anxiolytic and anticonvulsant activity. ELB-139 induces increase of extracellular 5-HT in the striatum and the medial prefrontal cortex of rats.
    ELB-139
  • HY-106504
    Aganodine 86696-87-9 98%
    Aganodine is a guanidine that activates presynaptic imidazoline receptors and can inhibit electrically evoked [3H]-norepinephrine release.
    Aganodine
  • HY-106644
    Femoxetine 59859-58-4 98%
    Femoxetine is a serotonin (5-HT) inhibitor with antidepressant properties. Femoxetine increases serotonin levels in the brain by preventing serotonin from being reabsorbed by nerve cells, resulting in increased concentrations of the neurotransmitter in the synaptic gap, which enhances serotonin signaling. Femoxetine can be used to study the role of serotonin in depression and other emotional disorders, and how 5-HT reuptake inhibitors affect mood and behavior.
    Femoxetine
  • HY-106747
    Ralitoline 93738-40-0 98%
    Ralitoline is a sodium channel blocker with IC50 of 2 μM. Ralitoline has anticonvulsant activity.
    Ralitoline
Cat. No. Product Name / Synonyms Application Reactivity